Which Progesterone in early pregnancy ...Excerpts from a webinar
NMP to manage threatened miscarriage and for luteal support in ART
DIVAGEST
Natural Micronized Progesterone in Early Pregnancy
A Special Lecture
by
Dr. S. Sampathkumari, Vice President FOGSI
Key Takeaways:
Progesterone provides nutrition and enables fetal development; suppresses uterine contraction; modulates the immune response of the mother to prevent embryo rejection in early pregnancy.
NMP used in early pregnancy from luteal phase until 8-10 weeks of gestation (or till luteal-placental shift occurs)
The vaginal route is the most preferred, followed by the sustained release oral route
Indicated for high-risk cases - in early pregnancy loss, threatened miscarriage, RPL, LPS, LPD, BOH, IVF
Both PROMISE and PRISM trials confirm that micronized vaginal progesterone is useful for early pregnancy & IVF.