Frozen Embryo Transfer cycles benefit more with addition of dydrogesterone to micronized progesterone for luteal phase support
Dydrogesterone is well-tolerated and probably contributes to the immunomodulation of the receptive endometrium. It can therefore be applied for luteal phase support in FET cycles.
PUBLICATIONS
The aim of this study was to compare five different progesterone regimens (DYD, MPG, DYD+MPG, MPC, and subcutan-P4) in the hormone replacement therapy and frozen embryo transfer (HRT-FET) cycles of a real-world population of women undergoing ART.
1) oral dydrogesterone (30 mg/day)
2) vaginal micronized progesterone gel (90 mg/day)
3) dydrogesterone (20 mg/day) plus micronized progesterone gel (90 mg/day) (dydrogesterone + micronized progesterone gel)
4) micronized progesterone capsules (600 mg/day)
5) subcutaneous injection of progesterone 25 mg/day (subcutan-P4)
In this study, the addition of dydrogesterone in luteal phase support in artificial frozen-thawed embryo transfer cycles was associated with higher clinical pregnancy rate (CPR) live birth rate (LBR) than the use of vaginal micronized progesterone gel alone
Dydrogesterone is well-tolerated and probably contributes to the immunomodulation of the receptive endometrium. It can therefore be applied for luteal phase support in FET cycles.