INDOMETHACIN IN TRIPLE THERAPY COMBINATION FOR PATIENTS OF RADIOULNAR SYNOSTOSIS.
Indomethacin – a triple therapy component in rare HO cases
In a post-traumatic radioulnar synostosis study of retrospective case series of 10 patients in Kuwait, radioulnar synostosis developed due to the most common cause -fractures.
A combination of adjuvant indomethacin, radiotherapy, and HO resection, followed by the insertion of an anconeus interposition flap was used in all 10 patients. Indomethacin dose and duration was 25 mg orally 3 times daily for a period of 2-4 weeks.
Results showed favorable outcomes with respect to range of motion, with improvements in flexion, extension, and rotation, as also the assessment of the subjective Mayo score.
Treating post-traumatic radioulnar synostosis with a combination of adjuvant indomethacin, radiotherapy, and tissue interposition with an anconeus flap after HO resection resulted in favorable functional outcomes and prevented recurrence in the study.